HYPERTRIGLYCERIDEMIA AND NON-HDL CHOLESTEROL IN THE DEVELOPMENT OF DIABETIC NEPHROPATHY

Olayiwola A. Popoola* and Olaniyan M. Folaranmi*

ABSTRACT

The risk of diabetic nephropathy in type 2 diabetes is about 30-40%, and it is considered the leading cause of end-stage renal disease. This Study is aimed to determine the association between non-HDL cholesterol and inflammation in the development of diabetic nephropathy and to identify a possible predictor for diabetic nephropathy in type 2 diabetic patients. Eighty diabetic subjects were recruited for the study; 40 diabetic and normoalbuminuric were used as positive controls and another 40 diabetic and microalbuminuric as test group and these subjects were compared with 98 non-diabetic controls. Lipid profile, CRP, HbA1c, microalbumin, were estimated and result expressed as mean±SD. The difference in mean for Total cholesterol, LDL, triglyceride, were statistically significant when diabetic group were compared with the non diabetic control P<0.01. Our result show higher levels of total cholesterol, non-HDL-C, triglyceride, CRP and in diabetic groups when compared with controls (p<0.01). Our data shows a positive correlation between microalbumin and non-HDL cholesterol (r=0.547,p<0.01), microalbumin and triglyceride (r=0.512,p<0.01) Non HDL cholesterol and triglyceride should be considered as a potential risk factor and as a diagnostic biomarker to be used in conjunction with other biochemical markers for early diagnosis, assessment, and follow-up of diabetic nephropathy.

Keywords: Diabetic nephropathy, normoalbuminuric, microalbumin, non-HDL-C, triglyceride, CRP.