FORMULATION AND EVALUATION OF CAPSULES CONTAINING PHYYTOSOMES OF PHYSALIS MINIMA LINN. FOR IMPROVED THERAPEUTIC OUTCOME

Nilakshi G. Mahakalkar*, Neelam Dighe and Dr. Jasmine G. Avari

ABSTRACT

Herbal drug having some limitation over oral drug delivery which includes poor solubility, permeation and bioavailability so as to improve these parameters of herbal novel drug delivery system known as phytosome is used. By applying this novel approach bioavailability is increased. The objective of the current project is to develop a herbal capsules loaded with phytosomes with a systematic approach to yield better products stability and it can be easily administered with oral drug delivery. It can improved acceptability and therapeutic potential owing to its greater bioavailability. Different phytosomal complexes of Physalis minima extracts containing a molar ratio of 1:1, 1:2, 1:4 using methanolic extract and soya lecithin were prepared by solvent evaporatiion technique. Physalis minima phytosomes were characterized by particle size, zeta potential, entrapment efficiency, Fourier transform infrared spectroscopy and in-vitro drug release. Prepared phytosomes showed 51 % entrapment efficiency, particle size (254nm), zeta potential (-7.57) and field emission scanning electron microscopy (FE-SEM) show spherical shaped particles. Physalis minima phytosome loaded capsule showed the capsules weight variation within the limit, disintegration time 10-13 min and in-vitro drug release of 93%. The drug content was found to be in the range of 69-83 % in all formulations.

Keywords: Phytosomes, novel drug delivery, entrapment efficiency.