FORMULATION & EVALUATION OF MEDICATED NAIL LACQUER OF FLUCONAZOLE

Deepa Dhiman*, Sunit Kumar and Aman Mittal

ABSTRACT

Topical therapy is desirable in treatment of nail diseases like Onychomycosis (fungal infection of nail) and psoriasis. The purpose of this study is to explore the difficulties in penetration of drug across nail plate & enhancement of bioavailability of antifungal drug. Many formulations of fluconazole were prepared namely F1, F2, F3 and F4 and evaluated for various processing parameters including in-vitro release (Diffusion) studies in 7.4 pH phosphate buffers. Effect of varying concentration of various excipients were studied after evaluated non-volatile content Drying time, film forming & diffusion rate, drug content analysis, antifungal activity, kinetics release studies. In drug excipients compatibility studies there was no chemical incompatibility between the drug and polymer. In in-vitro diffusion studies and in-vitro permeation studies it was found that formulation F3 showed better diffusion and permeation. On the basis of current investigation, this system may improve patient’s compliance.

Keywords: Nail Lacquer, Fluconazole, Ethyl cellulose, Toluene, Castor oil, Glycerin, Thioglycolic acid, Acetone.