DO STEM CELLS DIFFERENTIATE TO BACTERIA?

Alen J. Salerian MD*

ABSTRACT

Cumulative evidence suggests that some human endogenous infections may derive from bacteria produced by human cells. This study offers evidence to suggest that human stem cells are capable to produce microorganisms and represent the most likely candidates to generate microbes. The twin discoveries of A: The fetus is not sterile and harbors bacteria that are not contaminants and B: The Christensenellaceae bacteria are heritable and human genetics shape the gut microbiome, suggest some bacteria are produced by human cells. Human stem cells are capable to differentiate to epithelial and cancer cells and have the essentials to produce microbes. Human stem cells- consistent with their unique properties of multi-potency and self renewal - represent the most likely candidates to produce endogenous microorganisms, although this novel observation needs future experimental validation. Human cells represent a constant major source of new bacteria.

Keywords: Stem cells; Bacteria; endogenous infections; Christensenellaceae; Fetal bacteria.