AN OVERVIEW –ANALYTICAL METHODS FOR THE ESTIMATION OF FELODIPINE BULK AND IN PHARMACEUTICAL DOSAGE FORM

Sudha T.*, Priyadharshini B., Priyanka V., Nivetha S. and Pavithra V.

ABSTRACT

Felodipine is a medication used in the treatment of hypertension. It belongs to the dihydropyridine (DHP) class of calcium channel blockers. It is widely analysed by HPLC method. Felodipine can be analysed not only in neat solution but also in pharmaceutical products alone and in combination with other products. Felodipine is also used to prevent future heart diseases, heart attacks, angina and strokes. This review discusses the different analytical methods for the estimation of Felodipine. In this review the instruments used are HPLC methods, UV spectrophotometry, HPLC-UV, HPLC-MS, GC-MS, LC-MS, Chiral normal phase liquid chromatography and Electrospray ionization mass spectrometry, Chiral stationary phase chromatography and gas chromatography/mass spectrometry and Ultra sound assisted dispersive liquid-liquid micro extraction coupled with high performance liquid chromatography. A simple and sensitive stability indicating HPLC method was developed and validated for the quantitative determination of Felodipine in the presence of its degradation products, using atenolol as an internal standard. Moreover this review will be useful for further research and studies on felodipine.

Keywords: Felodipine, Calcium channel blocker, Hypertension, Spectroscopy.