FORMULATION DEVELOPMENT AND OPTIMIZATION OF EXTENDED RELEASE MATRIX TABLETS OF AZILSARTAN USING NATURAL AND SYNTHETIC POLYMERS

V.T. Iswariya*, G.L. Soujanya, Sai Santhoshi, Shobha Rani, Haseeba, Sabitha

ABSTRACT

The aim of the present study was to develop extended release formulation of azilsartan to maintain constant therapeutic levels of the drug for over 12 hrs. Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension. Xanthan gum, Chitosan and HPMC K15M were employed as polymers. Preformulations studies were carried out for all the parameters such as angle of repose, bulk density, tapped density and Hausners ratio were found to be good. Drug and excipient compatability studies were carried out using FTIR and DSC, based on the results the it was found that there were no interactions. Various quality control evaluation parameters were carried out and the results were found to be good.Whereas from the dissolution studies it was evident that the formulation (F10) showed better and desired drug release pattern i.e., 99.75% in 12 hours. It contains the natural polymer HPMC K15M as extended release material. It followed peppas release kinetics mechanism.

Keywords: Azilsartan, Xanthan gum, Chitosasn, HPMC, Extended release tablets.