STUDIES ON DESIGN AND DEVELOPMENT OF DISSOLVABLE ORAL DRUG DELIVERY SYSTEMS OF A POORLY WATER SOLUBLE NON-STEROIDAL ANTI- INFLAMMATORY DRUG

T. Sukanya*, S. Srivallika, D. Chandra Sekhar Naik, Aminul Islam Khan, Atif Hussain and Mehabub Hassan

ABSTRACT

The main objective of the present research work is to develop fast dissolving tablets by employing 23 factorial designs with Starch xanthate. The physical and micrometric properties were performed to evaluate the synthesized starch xanthate. The fast-dissolving tablet of Diclofenac was prepared by employing starch xanthate as superdisintegrantin different proportions in each case by direct compression method using 23 factorial design. Starch xanthate exhibited good swelling in water. The study between Diclofenac and starch xanthate was shown the absence of interaction by Fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC). The evaluation post parameters of fast dissolving tablets the optimized formulation is F2. The dissolution efficiency of Diclofenac was enhanced when starch xanthate was found to be a super disintegrants when combined with sodium starch glycolate, croscarmellose sodium and, hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 10 min.

Keywords: Fast dissolving, Superdisintegrant, Starch xanthate, Dissolution.