SOLID DISPERSION TECHNIQUE TO IMPROVE SOLUBILITY OF ACECLOFENAC

*Sri Lahari Tanniru, Sai Jyoshna Mudavath, Ramya Ghanapuram and Hyma Ponnaganti

ABSTRACT

Aceclofenac is confronted with challenge in conceiving appropriate formulation, due to low solubility and bioavailability. It is an analgesic and anti-inflammatory. aceclofenac is mainly used in treatment of ankylosing spondylitis, osteo arthritis, rheumatoid arthritis. To enhance the bioavailability of drug, Various compositions of aceclofenac solid dispersions were prepared by solvent evaporation method using mannitol and urea as carrier. The formulations evaluated for dissolution study and also characterized by FTIR study. Moreover, the study suggested the conversion of crystalline aceclofenac. And it shows no interaction between carrier and drug. Among all the formulations optimized formulation shown higher drug release% compared to other formulations. As compared to the pure drug, In vitro release rate of aceclofenac solid dispersion showed significant improvement.

Keywords: Anti-inflammatory, bioavailability, osteoarthritis, crystalline, solid dispersion, dissolution, ankylosing spondylitis.