ASSESSMENT OF THE EFFECTS OF THE AQUEOUS EXTRACT FROM TRUNK BARK OF PARKIA BIGLOBOSA (MIMOSACEAE) ON GLYCEMIA, RELEASE AND STORAGE OF HEPATIC GLUCOSE IN HEALTHY AND STREPTOZOTOCIN-INDUCED DIABETIC RATS

Toto Kouamé Noël*, Goh Bi Lane Adrien, Kassi Yomalan, Semi Anthelme Nene Bi and Traoré Flavien

ABSTRACT

Objective: Parkia biglobosa (Mimosaceae), is a plant commonly used in traditional African medicine to treat many diseases including hypertension, cardiac disorders and diabetes. This work aims to evaluate the effects of an aqueous extract from trunk bark of Parkia biglobosa (Mimosaceae) on blood sugar, the release and storage of hepatic glucose in healthy and diabetic rats. Methods: The measure of released glucose and glucose stored in the liver is performed using the reagent GOD-POD glucose in normoglycemic and diabetic rats. The blood sugar measure was performed on fasting rats using a glucometer. The animals were treated with glibenclamide at dose of 10 mg/Kg B.W and the aqueous extract of trunk bark of Parkia biglobosa at doses of 500 and 1000 mg/Kg B.W respectively. Results: The administration of EAqPB at doses of 500 and 1000 mg/Kg B.W reduced the release of liver glucose in normoglycemic rats after 60 minutes, with a significant percentage reduction (p<0.0001) of 13.83% for the group treated at a dose of 1000 mg/Kg B.W EAqPB. After 90 days of treatment, EAqPB at a dose of 1000 mg/Kg B.W, causes a significant decrease (p<0.0001) in blood glucose of diabetic rats by 58,79%. Moreover, after 90 days of treatment, EAqPB causes a significant increase (p˂0.0001) of hepatic glucose stored in rats rendered diabetic by 142%. Conclusion: The study showed that the extract inhibits hepatic glucose release in normoglycemic rats and significantly reduces hyperglycemia in diabetic rats. In addition, EAqPB promotes the glucose storage in the liver of diabetic rats.

Keywords: Diabetes, Parkia biglobosa, Streptozotocin, blood sugar, glycogenogenesis and glycogenolysis.