NEW DRUG DISCOVERY AND DEVELOPMENT

Dr. Bhawna Sharma*, Saddam, Dr. Upendra Kumar Sharma and Rizwana Khan

ABSTRACT

The establishment of a novel drug is still a costly, prolonged, difficult, and inefficient process with a high attrition rate of new therapeutic discovery. This approach can cost pharmaceutical companies an average $2.6 billion and 10–15 years of research and development. Drug design is the innovative process for the discovery of new medications, involves the design of new therapeutic entities that are complementary in shape and charge to the molecular target with which they interact and bind. A traditional approach is one of the oldest methods for finding new drugs of natural origin, involves the investigation of medicinal substances of plant, animal, or mineral origin in their crude or unprepared state. On the other hand, ultra-high-throughput drug screening and combinatorial chemistry-based development are being heavily employed to reduce the cost and the time of early drug discovery. The present review article will look deeper into the key concepts of drug discovery, drug development and clinical stages of the drug discovery. Our main objective of the review is to assist scientists whose research may be related to drug discovery and development to shape their research report in a way that relevantly places their findings into the drug discovery and development process, hence supporting effective and translation of preclinical research to humans.

Keywords: Drug discovery, Clinical researches, clinical trials, phases of clinical trials, Investigational drug, and Generic drug.