A COHORT STUDY OF THYROID HORMONE IN PEDIATRICS: CORRELATION WITH OBESITY IN SAUDI ARABIA

Turki Melfi Alharbi*, Faisal Hadi Almilfy, Faisal Abdullah Al-Abduljabar, Wail Altreef, Amal Abdulrahman Alsowaidi, Mohammad Abdulrahman Althnayan, Mohammed Abdulaziz Alkhalifah, Arwa Abdulaziz Almajdui, Alanoud Saleh Albuloshi, Abrar Abdulaziz Al-Ajlani, Mohammed Faisal Alsamih, Faisal Mohammed Alshehri, Faisal Abdullah Alabduljabar, Abdullah Abdulaziz Aleid, Abdullah Kulip Alonzi and Amani Abdullah Alharbi

ABSTRACT

For children to grow or increase in height properly they need adequate levels of need growth hormone (GH) or somatotropin (Qiu H, 2017), and thyroid hormone also is essential for bones development in childhood and regulation in adulthood, and they both have many other effects, and growth hormone disorders can cause growth abnormalities weather it is excess production or decrees, the coloration between growth hormone and thyroid hormone is important because secretion and action of both hormones can be effected by each other (Cabello G, 1989), although thyroid stimulating hormone (TSH) is the main thyroid hormone regulator other factors can affect the thyroid hormone including growth hormone, also thyroid can affect growth hormone, increased levels growth hormone have been can lead to acromegaly, and patients of acromegaly can also develop goiter an from an enlarged thyroid gland (Cabello G, 1989), and patients who suffer from decreased levels of growth hormone and receive growth hormone replacement therapy can develop alterations in the hypothalamic-pituitary-thyroid axis, and can result in different changes wither it is a decrees in thyroxine (T4) levels or no changes, also triiodothyronine (T3) it can be in variable changes in can be increased or unchanged. (Glynn N, 2016). There is wide verity of possibilities that can be the cause of these and other possible changes, in this study we aim to understand growth hormone correlation with thyroid hormones in children who take growth hormone replacement therapy, and evaluate the entire hypothalamic–pituitary–thyroid axis, and the thyroid hormone function in this situation, and the potential effect of these interaction and the clinical results, and improve our understands of these situations to try and improve the treatment.

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