AN OVERVIEW OF BILAYER TABLET TECHNOLOGY

Dipali B. Shinde*, Rushikesh B. Shinde, Bhagyashree R. Dhambore and Hemangi S. Binnar

ABSTRACT

Bilayer tablet is a novel approach to achieve controlled release of a drug with predefined release pattern from the last few years, interest in designing and formulating of two or more Active Pharmaceutical Ingredients (API) in single dosage form ( bilayer tablet) for treatment of a disease. bilayer tablet dosage form also promotes customer compliance and convenience. The scientists work on to developed and formulating bilayer tablets to increase the therapeutic activity of a drug .e.g diabetes, and hypertension are two chronic diseases that may coexist, the major cause of death in the diabetes mellitus patient is heart disease. So to achieve the required therapeutic effect combine nebivolol and nateglinide for better patient treatment. Bilayer tablet technique is a modified beneficial method to get a better effect as compared to single-layer tablets. This technology provides an important approach for developing and designing not only incompatible drugs but also drugs with different release patterns. sustained-release tablets are formulated by this method in which the first layer is immediately released as loading dose and the second layer is maintenance dose, the release of a drug carried out without interfering pharmacokinetic and pharmacodynamic parameters with their dose of a drug. This review focuses on various application of bilayer tablet such as synergic property, antagonistic property; certain challenges in the formulation of bilayer tablet and also explain the need to develop and design quality bilayer Tablets with tablet press using a modified tablet press to produce a high-quality bilayer tablet with GMP parameter, mainly when high production yield require.

Keywords: bilayer tablet, GMP preparation require, tablet press, evaluation parameter for bilayer tablet.