EVALUATION OF HYPOGLYCEMIC ACTIVITY OF HOLARRHENA ANTIDYSENTERICA LEAVES EXTRACT IN STREPTOZOTOCIN INDUCE DIABETIC TARS

Mohd Ajam*, Dr. Nasiruddin Ahmad Farooqui, Dr. Shamim Ahmad and Jiyaul Hak

ABSTRACT

The current study is an effort to examine the effect of Holarrhena antidysenterica leaves extract on streptozotocin induced diabetes in Wistar rats. Two groups of streptozotocin induce diabetic rats were orally treated through Holarrhena antidysenterica leaves extract (250 and 500 mg/kg) respectively. The blood glucose level, body mass, Glycosylated hemoglobin, liver glycogen, lipid profile, Antioxidant status were measured at the end of the study that is after 28 days of treatment. Holarrhena antidysenterica leaves extract were originate to be significant (p < 0.001) in dropping the blood glucose level, liver and renal function, hemoglobin, triglyceride, cholesterol, blood urea, lipid profile, while both the treatments improved body weight, liver glycogen satisfied status once compared to the diabetic control. It have been concluded that Holarrhena antidysenterica leaves extract, in adding to the antidiabetic activity in the streptozotocin induced diabetic model.

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