EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND BIOLOGICAL EVALUATION OF A NEW SERIES OF QUINAZOLINONE INTEGRATED NOVEL PYRAZOLE VIA CHALCONE

Komal Savaliya* and Pankaj S. Patel

ABSTRACT

In the present investigation a new class of Pyrazole derivatives containing Quinoline moiety has been designed and synthesized by refluxation of 6,8-dibromo-3-{4-[3-(substitutedphenyl) prop-2-enoyl]phenyl}-2-phenylquinazolin-4-one (0.01M) and 99% hydrazine hydrate (0.015M) by using ethanol (50ml) as a solvent. The intermediate 6, 8-dibromo-3-{4-[3-(substitutedphenyl) prop-2-enoyl] phenyl}-2-phenylquinazolin-4-one synthesized by condensation of 3-(4-acetylphenyl)-6,8-dibromo-2-phenylquinazolin-4-one with various aldehydes in presence of ethanol. The product is characterized by spectral and analytical data. The chemical structures of the products are confirmed by IR, NMR and spectral data.

Keywords: Pyrazole, Chalcone, Antimicrobial activity, Antifungal activity, Agar cup method.

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SJIF Impact Factor: 7.065

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New Issue Published
Its Our pleasure to inform you that, EJPMR 1 November 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

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EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH