MULTISYSTEM INVOLVEMENT IN WEGENER’S GRANULOMATOSIS – A CASE REPORT

Dr. Ranjit Kaur, Dr. Ketaki Kainth and Dr. Ashish Kumar*

ABSTRACT

A 36 years male presented with gradually progressive shortness of breath associated with decreased hearing and blurring of vision, with repeated episodes of sinusitis. Examination revealed saddle nose and high frequency hearing loss. Further, blood investigations showed anemia with acute kidney injury and hematuria with macroscopic proteinuria. cANCA was positive. Renal biopsy suggested pauci immune glomerulonephritis. FESS showed septal perforation with granuloma formation and necrosis. MRI brain showed findings suggestive of optic neuritis. This case presented with typical presentation of wegener’s granulomatosis, symptoms ignored by patient for 4 years, and came to care only after renal failure has developed. Patient was managed with pulse therapy with cyclophosphamide and hemodialysis support.

Keywords: Granulomatosis with polyangiitis, Wegener's granulomatosis, optic neuritis.