EVALUATION OF DIURETIC AND LAXATIVE ACTIVITY OF METHANOLIC EXTRACT OF XANTHIUM STRUMARIUM L. (ASTERACEAE) LEAVES IN ALBINO WISTAR RATS

*Munigolla Muni Homapriya and Dr. P. Dharani Prasad

ABSTRACT

Xanthium Strumarium L. common cocklebur, large cocklebur, woolgarie bur is a species of annual plants of the family (Asteraceae). It is extensively used for treating gastrointestinal conditions, skin diseases, allergic reactions and inflammatory conditions. The present study was evaluated for diuretic and laxative activity of methanolic extract on albino wistar rats. The acute toxicity study of the extract had shown no sign of toxicity up to a dose level of 2000mg/kg body weight. The methanol extract of Xanthium Strumarium L. (200mg/kg) showed lesser diuretic activity compared to MEXS 400mg/kg during the 5h of the test duration (Diuretic action (4.53 and 5.75) when compared to control the MEXS 200mg/kg MEXS 400mg/kg both doses showed more significant diuretic activity. The laxative activity of Xanthium Strumarium L. was after oral administration of extract showed the significant and dose-dependent increase in fecal output of rats in regards to the accumulation of water in the intestine. Xanthium Strumarium L. (200mg/kg) showed lesser laxative activity compared to MEXS 100mg/kg during the 8h of the test duration (Laxative action (2.71 and 3.23) when compared to control the MEXS 100mg/kg MEXS 200mg/kg both doses showed more significant laxative activity.

Keywords: Xanthium Strumarium L., Diuretic, Laxative, cocklebur, Significant etc.