A REVIEW ON MICROPARTICULATE DRUG DELIVERY SYSTEM FOR COLON TARGETING

*Sachin G. B. and Dr. Parthiban S.

ABSTRACT

Colon-specific drug delivery systems are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions. Drugs such as proteins and peptides that are known to degrade in the extreme gastric pH, if delivered to the colon intact, can be systemically absorbed by colonic mucosa. In order to achieve effective therapeutic outcomes, it is imperative that the designed delivery system specifically targets the drugs into the colon. Several formulation approaches have been explored in the development colon-targeted drug delivery systems. Microparticles as colon drug delivery System has gained importance for the delivery of the drug in the colon because of their increase biocompatibility, controlled release of drug and higher stability. This review is discussing in brief about introduction to colon targeted drug delivery, Microparticle as colon drug delivery system. Oral delivery is still the most favourable route of drug administration, especially for chronic therapies where repeated administration of drug is required. Oral administration offers less pain, good patient convenience and reduced risk of cross infection and needle stick injuries.

Keywords: Colon targeted drug delivery, microparticles, approaches, preparation of microparticles etc.