CLINICAL EFFICACY OF TRAMADOL AS AN ADJUVANT TO CHLOROPROCAINE IN SPINAL ANAESTHESIA FOR INFRA-UMBILICAL SURGERIES: A PROSPECTIVE RANDOMIZED DOUBLE BLIND STUDY

Dinesh Chand Meena, Khemraj Meena, Ravindra Kr. Gehlot*, Alka Yadav and Pramila Kumari

ABSTRACT

Introduction: Spinal anaesthesia is a reliable and safe technique for procedure of the lower abdomen and lower extremities. Aim of this study to evaluate the effect of tramadol as an adjuvant with intrathecal isobaric chloroprocaine in infraumbilical surgeries. Material &Methods: Clinical Trials Registry India (CTRI/ 2019/04/018539) registration and taking informed written consent from the patients, this prospective, double blind study in patients with ASA grade I and II of either sex, age 18-60 years, posted for Infra-umbilical surgeries under spinal anaesthesia was carried out at our institute. Eighty patients were randomly divided into two groups (n=40): Group (CT)- Patients received 1% Chloroprocaine 4 ml (40 mg) + Tramadol 0.5 ml (25 mg) total volume 4.5 ml. Group (CS)- Patients received 1% Chloroprocaine 4 ml (40 mg) + Normal Saline 0.5 ml total volume 4.5 ml. Sensory and motor block characteristics, vital parameters and any adverse effects were noted in a performa. Results: Time to sensory block regression to S1 was significantly longer in group CT (123.98±9.34min) as compared to group CS (108.85±8.56min). Time to first rescue analgesia was significantly longer in group CT (92.45 ±9.64 min) as compared to group CS (84.75±8.43min). Time to motor block regression to B0 was significantly longer in group CT (105.80±7.91min) as compared to group CS (87.60±8.07min) [P=0.000]. Both the groups were statistically comparable regarding vital parameters during intra-operative period [P>0.05]. Conclusion: Hence we recommend the addition of Tramadol (25 mg) as an adjuvant to isobaric Chloroprocaine 1% (4ml) for the patients undergoing infraumbilical surgeries under subarachnoid block.

Keywords: Chloroprocaine, Tramadol, Infraumbilical surgery, Subarachnoid block.