GALLSTONES AND LIVER FUNCTION

Khalid Ekrim, Naser M. Al-aasswad*, Abdall. A. Alsayah and Ibrahim AM Eshnaf

ABSTRACT

The gallbladder is a small musculo-membranous hollow organ, located directly under the liver. It stores and concentrates bile produced in the liver, which aids in the digestion of fats in the duodenum. An excess of cholesterol, bilirubin, or bile salts can cause gallstones to form. Gallstones are generally small, hard deposits inside the gallbladder that are formed when stored bile crystallizes. The aim of this research is to classify the different types of gallstones and study their relationship to liver function. Samples were collected from 66 patients who underwent a cholecystectomy in Fezzan Clinic in Sebha. Venous blood samples were collected and taken to the laboratory for complete blood analysis, blood groups and liver function. The results of this study showed that the age of the participants was 40.6 ± 12.7 years, and that the age group of 45-19 years (69.7%) was more affected, and that females were more susceptible to gallstones than males. The study showed that the hematological profile that were studied were in the normal range and (37.9%) were found to have a low haemoglobin concentration. And that the most group susceptible to gallstones is (O+). This study showed that pigmented gallstones were the most common types of gallstones, followed by cholesterol stones and mixed stones. The study showed that (36.4%) of the samples had a regular shape and (63.6%) of the samples had an irregular shape. And that (51.5%) had a smooth texture and (48.5%) had a rough texture. While the results showed that there were no significant differences for both bilirubin and Glutamic Pyrovate Transaminase (GPT) enzyme, while an a significant differences was found in both Glutamic Oxaloacetate Transaminase (GOT) and Alkaline phosphatase (ALP) enzymes between the different species of gallstones.

Keywords: gallbladder, gallstones, hematological profile, liver function, pigmented and cholesterol.