REVIEW ON SOLID LIPID NANOPARTICLE FOR MUCOSAL DRUG DELIVERY SYSTEM

Nurul Amin*, Sheikh Sofiur Rahman and Chinmoy Bhuyan

ABSTRACT

Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. SLNs are solid core lipid nanocarriers, which can hold both hydrophilic and hydrophobic drugs. They can be made up of biocompatible ingredients and therefore are one of the preferred choices for drug delivery. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. Mucosal drug delivery involves administration to moist cavities, such as the lining of the mouth, vagina, and bladder. Mucosal drug delivery systems possess additional advantages, such as close contact with the mucosal surface, when compared to other approaches. The MDDS provides a high surface to volume ratio and longer residence time, resulting in effective absorption and increased the bioavailability of the drug. In this review, attention is focused to give regarding solid lipid nanoparticles advantages, disadvantage. Mucosal drug delivery systems advantages, limitation, Physiological Importance of Mucins and Saliva. Methods of preparation of SLNs, influence of various excipients in SLNs, characterization of the SLNs, application of SLNs.

Keywords: Solid lipid nanoparticles, Mucosal drug delivery systems, Nanostructured lipid carriers, Routes of administration, Influence of excipients.