DESIGN AND SYNTHESIS OF NEW SERIES OF 5-[3-(SUBSTITUTEDPHENYL)-1-{4-[2- (4-CHLOROPHENYL)-4-OXO-1,3-THIAZOLIDIN-3-YL]PHENYL]PROP-2-EN-1- YL}PYRIMIDINE-2,4,6-TRIONE DERIVATIVES

Nital N. Patel and Pankaj S. Patel*

ABSTRACT

Heterocyclic Compounds have so far been synthesized mainly due to the wide range of biological activities. Thiazolidinone plays an important role in biological field. From these reviews we synthesized a new series of 5-[3- (substitutedphenyl)-1-{4-[2-(4-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]phenyl]prop-2-en-1-yl}pyrimidine-2,4,6- trione derived from 3-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-(4-chlorophenyl)-1,3-thiazolidin-4-one and barbituric acid in CH3COOH. The title compounds were characterized by element analysis, IR, NMR and spectral data. All the compounds were tested for their antibacterial and antifungal activities by Cup Borer method.

Keywords: Thiazolidinone, Trion, IR, NMR, Cup Borer method.