GAMMA GLUTAMYL TRANSFERASE AS A MARKER IN METABOLIC SYNDROME

Dr. Vaishnavi Alam*, Dr. V. Lakshmaiah, Dr. Prabhakar K., Dr. Harish Kumar, Dr. Reddy Prasad,
Dr. Sumathi

ABSTRACT

To study the association of Gamma Glutamyl Transferase levels with metabolic syndrome and To compare and correlate biochemical parameters between controls and cases. Materials and Methods: This is a case control of study of 110 subjects in R.L. Jalappa hospital both inpatients and outpatient of which included are 55 subjects who satisfy IDF criteria for metabolic syndrome and 55 age and sex matched controls. Blood pressure, waist circumference , Liver function tests including GGT, AST, ALT and ALP, Lipid profile, Fasting plasma glucose, Thyroid profile, Renal function tests and USG abdomen were performed in subjects. Results: The mean values of GGT, alanine amino transferase(ALT), aspartate aminotransferase (AST) levels were statistically significantly higher in MS group. The mean values of liver enzymes, in MS group, GGT, AST and ALT respectively, were; 51.89±6.31, 31.80±17.37 and 37.71±13.52. In the study sample, increase in GGT was positively correlated with increased MS prevalence. In ROC analysis, GGT is as strongly associated with the IDF diagnostic components as is each individual IDF component, except elevated systolic blood pressure. In covariance analysis, there was significant relationship between elevated GGT levels and MS presence after adjustment for age, sex and MS diagnostic criteria. In multivariance analysis, in MS group, a high GGT was positively associated with CVD prevalance compared to low GGT group independent of age, sex and smoking habits. Conclusion: Elevated liver enzymes, although in normal ranges, especially at upper quartiles, play a central role in early diagnosis of fat overflow to the liver. Regarding the availability and simplicity of these tests in routine clinical practice, they, especially GGT, have potential to be considered in algorithms for metabolic syndrome.

Keywords: To study the association of Gamma Glutamyl Transferase levels with metabolic syndrome and To compare and correlate biochemical parameters between controls and cases. Materials and Methods: This is a case control of study of 110 subjects in R.L. Jalappa ho