REVIEW ON ANALYTICAL METHODS OF RUFINAMIDE

Priti Shirsath*, Vidya Shirsath, Sagar Dalvi, Komal Navale and Hemlata Bhawar

ABSTRACT

Rufinamide is a drug used to treat seizures and also used in combination with other drug to treat Lennox–Gastaut syndrome. Rufinamide particularly prolongation of the inactive state limiting the sustained bursts of high-frequency action potentials and preventing sodium channels from returning to an activated state, therefore decreasing the neuronal hyperexcitability and action potential propagation. For the determination of rufinamide in pharmaceutical dosage form and bulk form, several analytical methods including HPTLC, UV and HPLC has been developed. Developed methods are stability indicating, impurity profiling human plasma are also described for rufinamide. For qualitative and quantitative estimation of rufinamide these analytical methods can be used and it can also be used for its related degradants in bulk formulations and biological fluids. The following study depicts the review on analytical methods which includes to estimate the Anti- Seizures drug.

Keywords: Rufinamide, HPLC, Analytical Methods, seizures, Lennox–Gastaut syndrome.