DEVELOPMENT AND VALIDATION OF SIMPLE UV SPECTROSCOPIC METHOD FOR THE QUANTIFICATION OF OXYBUTYNIN HYDROCHLORIDE IN BULK AND MARKETED TABLETS

Spoorthy Narayandas and Yegnoor Anand Kumar*

ABSTRACT

Two Simple and precise UV spectroscopic methods developed and validated as per ICH guidelines. The solvent systems such as 0.01M HCl and double distilled water selected for the study. The two proposed solvent systems validated for linearity, accuracy, precision, robustness, ruggedness and solution stability. The percent recovery in the marketed tablet formulation is with god agreement with the label claim. The proposed methods validated statistically by linearity, precision, repeatability, reproducibility, specificity and solution stability. The results suggest these methods can employ for the routine analysis of oxybutynin hydrochloride in bulk as well as marketed tablet formulations. The results suggest these methods can employed for the routine analysis of oxybutynin hydrochloride in bulk as well as marketed tablet formulations.

Keywords: Oxybutynin hydrochloride, UV spectroscopy, Validation, Accuracy, Precision.