EVALUATION OF ANALGESIC ACTIVITY OF SIDDHA HERBAL DRUG KEELVAYU NIVARANA CHOORANAM BY ACETIC ACID INDUCED WRITHING RESPONSE METHOD

T. Giftillda Selva Elsee*, M. D. Saravana Devi, K. Rajammadevi Sorubarani and V. Velpandian

ABSTRACT

The Siddha herbal formation Keelvayu Nivarana Chooranam (KVNC) was studied for its in vivo analgesic activity by acetic acid induced writhing response method in Wister Albino Rats. KVNC has four ingredients which includes Nannariverpattai Chooranam (Hemidesmus indicus), Parangipattai Chooranam (Smilax chinensis), Seemai Amukara Chooranam (Withania somnifera), Chittaraththai Chooranam (Alpinia officinarum) and mentioned in Siddha literature for treating Keelvatham (Arthritis). Pain is an unpleasant sensation localized to a part of the body and can be debilitating. People are looking for treatment with cost effective and less adverse drug reactions. This study was aimed to compare the test drug with the standard drug. Wistar albino rats were divided into four groups (n = 6). Group I received acetic acid, Group II received aspirin (100 mg/kg b.w.p.o.) Group III and IV received KVNC at the doses of 100 mg/kg and 200 mg/kg b.w., p.o. respectively. Five minutes after the acetic acid injection, the number of times that each animal presented abdominal constriction was counted for 15 consecutive minutes. Percentage of inhibition in Group II (Standard drug) shows 84.85%, Group III (KVNC 100mg) shows 75.76%, Group IV (KVNC 200mg) shows 78.79%. The Drug KVNC exhibited potent analgesic effects in animal model.

Keywords: Analgesic activity, Siddha drug, Keelvayu Nivarana Chooranam, Writhing test