COMPARATIVE BIOAVAILABILITY OF TURMERIC EXTRACT 65% + BLACK PEPPER EXTRACT 95%, TURMERIC EXTRACT 65% + BLACK PEPPER EXTRACT 40% AND TURMERIC EXTRACT 95% + BLACK PEPPER EXTRACT 95% CAPSULES OF BOTANIC HEALTHCARE PVT. LTD. VS TURMERIC EXTRACT 95% + BIOPERINE CAPSULES IN HEALTHY ADULT HUMAN SUBJECTS UNDER FASTING CONDITIONS

Dr. Harish S.*, Savita Pawar, Madhu Krishnamani, Gaurav Soni and Dr. Sneha V. P.

ABSTRACT

Background: Curcumin has a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic, immune-modulating, metabolism regulating, anti-depressant, and neuroprotective and tissue protective effects. However, its poor solubility and poor absorption in the free form in the gastrointestinal tract and its rapid biotransformation to inactive metabolites greatly limit its utility as a health-promoting agent and dietary supplement. Recent advances in micro- and nano-formulations of curcumin with greatly enhanced absorption resulting in desirable blood levels of the active forms of curcumin now make it possible to address a wide range of potential applications, including pain management, and as tissue protective. Using these forms of highly bioavailable curcumin now enable a broad spectrum of appropriate studies to be conducted. A randomized, open label, analyst blind, balanced, four-treatment, four-arm, parallel, single dose, study was designed to evaluate the Comparative Bioavailability of Turmeric extract 65% + Black pepper extract 95%, Turmeric extract 65% + Black pepper extract 40% and Turmeric extract 95% + black pepper extract 95% capsules of Botanic Healthcare Pvt. Ltd. Vs Turmeric extract 95% + bioperine capsules of Sabinsa Corporation. Objectives: To compare bioavailability of Turmeric extract 65% + Black pepper extract 95%, Turmeric extract 65% + Black pepper extract 40% and Turmeric extract 95% + black pepper extract 95% capsules of Botanic Healthcare Pvt. Ltd. Vs Turmeric extract 95% + bioperine capsules in healthy adult human subjects under fasting conditions. Conclusion: The study concludes that the Test product-1 (T1): Turmeric extract 65% + Black pepper extract 95% capsules of Botanic Healthcare Pvt. Ltd. Are Relative bioavailable to the Reference product, Test product-2 (T2): Turmeric extract 65% + Black pepper extract 40% capsules of Botanic Healthcare Pvt. Ltd. are Relative bioavailable to the Reference product, Test product 3 (T3): Turmeric extract 95% + black pepper extract 95% capsules of Botanic Healthcare Pvt. Ltd. are Relative bioavailable to the Reference product; Turmeric extract 95% + bioperine capsules of Sabinsa Corporation.

Keywords: Bioavailability, demethoxycurcumin, Curcumin solubility, absorption, Human study.