A REVIEW ON SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF HMG-COA REDUCTASE INHIBITORS (STATINS)

Padmanabh B. Deshpande*, Snehal R. Dhamodkar, Jay Y. Mehta and Sushant V. Deshpande

ABSTRACT

Statins are lipid lowering medications used in the primary and secondary prevention of coronary heart disease by blocking HMG Co-A reductase, the rate limiting enzyme in cholesterol biosynthesis. There has been significant research on wide range of analytical techniques that could be useful in the estimation of inhibitors in formulations and biological matrices. Spectrophotometry includes the estimation of the substance concentration with the absorbance of visible or UV light by the substance and comparing it with standard values, measured under identical conditions. This method is widely used for industrial and research purposes, since it is relatively inexpensive, easy to carry out and can be done in a routine manner. This review is intended to give an insight into some of the spectrophotometric methods reported for the determination of Lovastatin, Simvastatin, Pravastatin, Atoravastatin, Rosuvastatin, Pitavastatin in pure forms, in different pharmaceutical dosage forms.

Keywords: Lovastatin, Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin, Spectrophotometric methods.