FAST DISSOLVING SUBLINGUAL FILM OF POORLY SOLUBLE DRUG

Shubham U. Jana* and Dr. Mohammad Wais

ABSTRACT

Delivery of drugs through oral mucosa is considered to be most promising offering better patient compliance. In some cases of serious illness, treatment is necessary for immediate onset of action. Delivery of drugs in the sublingual mucosa is regarded as a promising route to speed direct absorption of the drug into the systemic circulation. In the buccal cavity, the sublingual area facilitates deep penetration of drug and rapid absorption. Part of the drug absorbed through the sublingual blood vessels bypasses the hepatic first pass metabolism, which leads to greater bioavailability and offer a lot of advantage to geriatric, pediatric, elderly, and psychiatric patients with dysphagia. This review highlights sublingual film, factors that affect sub-lingual absorption, method of preparation, various in vitro and in vivo test parameters and marketed films.

Keywords: Sublingual film, permeability, bioavailability, first pass metabolism, dysphagia.