A COMPARATIVE STUDY ON ANTIMICROBIAL ACTION OF KARANJA ARKA AND GOMUTRA ARKA IN DUSTAVRANA WITH SPECIAL REFERENCE TO VENOUS ULCER

Dr. P. V. Vijay Guptha*, Dr. Syeda Ather Fathima, Dr. Shivalingappa J. Arakeri, Dr. Mohasin Kadegaon and Dr. Geethanjali Hiremath

ABSTRACT

Acharya Sushruta defines vrana as, a wound when heals leave a scar which remains till death. Any Vrana which gets dushita (dosha, or other factors) is called Dustavrana. In modern science, ulcer refers to discontinuity in the covering epithelium, skin or mucous membrane and may either follow molecular death of surface epithelium or its traumatic removal. Venous ulcers constitute 81% of leg ulcers. India has high prevalence rate of 4.5 cases per 1000 population in a year. Antimicrobial resistance is a global health and development threat. Misuse and overuse of antimicrobials are the main drivers in the development of Drug-resistant pathogens. A total 40 patients were randomly allotted into 2 groups namely group A with trail drug i.e. Karanja Arka and group B with standard drug i.e. Gomutra Arka with 20 patients in each group. Assessment was made on subjective parameters like pain, itching, swelling, foul smell and objective parameters like size, margin, floor, discharge, bacteria, culture & sensitivity response to 1st line of antibiotics. Observations were made before and after treatment. Assessment of organism, gram stain, azithromycin, amikacin, cefixime, ceftriaxone, ciprofloxacin, doxycycline, gentamicin, levofloxacin, linezoild, norfloxacin & tetracycline in group A showed 43.58%, 46.66%, 41.02%, 36.36%, 18.84%, 17.39%, 32.43%, 40%, 37.03%, 27.77%, 14.28%, 35.55%, 38.23% improvement and in group B 30.43%, 30.30%, 38.09%, 36.92%, 14.75%, 14.51%, 34.09%, 30.765, 37.50%, 37.83%, 9.25%, 30.95%, 17.14% improvement respectively. Based on the data we can say Karanja Arka is more efficacious than Gomutra Arka in Antimicrobial activity.

Keywords: Dustavrana, Arka, Antimicrobial resistance.