ANALYSIS OR INVESTIGATION & REPORTING OF ADVERSE DRUG REACTIONS REVIEW OF THE CURRENT SCENARIO, OBSTACLES AND POSSIBLE SOLUTIONS

Vandna Dewangan*, Saraswati Sahu, Ram Sahu and Trilochan Satapathy

ABSTRACT

Medication-related adverse events or adverse drug reactions (ADRs) are harmful events caused by medication. Adverse drug reactions (ADRs) could have profound effects on the patients’ quality of life, as well as creating an increased burden on the healthcare system. Adverse drug reactions are one of the rising causes of morbidity and mortality internationally, and will continue to be a significant public health issue with the increased complexity in medication, to treat various diseases in an aging society. identified that the most causes of ADRs were drug related and due to allergies and This scoping review aims to provide a detailed map of the most common adverse drug reactions experienced in primary healthcare setting, the drug classes that are most commonly associated with different levels or types of adverse drug reactions, causes of adverse drug reactions, their prevalence and consequences of experiencing adverse drug reactions. The most common adverse drug reactions (ADRs) reported in the studies included in this review were those that are associated with the central nervous system (CNS), gastrointestinal system (GI) and cardiovascular system (CVS). Several classes of medications were reported to be associated with adverse drug reactions (ADRs).

Keywords: Adverse drug reactions, Pharmacovigilance, World health organization, Fatigue, blood cell count, Nerve injury, Dizziness, cardiovascular system (CVS), nervous system, gastrointestinal, Drug-related side effects.