STUDY OF PATTERNS OF ANTIBIOTIC SENSITIVITY OF URINARY TRACT INFECTIONS

Dr. Suharshi Gupta*

ABSTRACT

Background: Urinary tract infections (UTIs) are one of the most common bacterial infections in human. Catheter-associated UTIs are one of the most dangerous health risks contributing 34% of all health care associated infections. Extensive and inappropriate use of antimicrobial agents has resulted in the development of antibiotic resistance which has become a major problem worldwide. The objective of the present study was to highlight the bacterial etiology of UTIs and determination of resistance pattern of E. coli isolates. Method: A cross-sectional prospective study was carried out in the Department of Microbiology, Govt. Medical College, Jammu (J&K), India, over a period of 6 months, i.e. from April 2021 to September 2021, among the reported OPD and indoor patients of GMC Jammu, in the age group of 18 to 90 years. Results: Of the 894 urine samples processed 455 (50.89%) gave significant growth of pathogens. The patients were between 18 and 90 years of age. The prevalence of UTI was high among females (63.08%) than males (36.92%). Females of the reproductive age group (18-49 years) constituted 53.40% of the total patients with UTI. However, elderly (50-90 years) males had a higher incidence of UTI (10.11%) compared to the elderly females (9.67%). Rate of E. coli (264, 58.02%) isolation was highest followed by Staphylococcus aureus (51, 11.2%). E. coli was found sensitive to meropenem, imipenem and amikacin (almost 100%), with good susceptibility to Ciprofloxacin (88%). Overall, 97% of the isolates were sensitive to Imipenem, 98.1% to Meropenem, while 90.3% are sensitive to Amikacin, 81.1% to Nitrofurantoin and 70.4% to Gentamicin. Conclusion: Culture positive rate for uropathogens was high, majority coming from adult female patients. E.coli was the most common etiological agent but still susceptible to nitrofurantoin. Nitrofurantin, Imipenem and Amikacin are good choice to tackle the upcoming problems of ESBL producing E.coli.

Keywords: Urinary Tract infection, Escherichia Coli, Prevalence, Antibiotic Sensitivity.