ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF PSEUDOMONAS AERUGINOSA CLINICAL ISOLATES AT A TERTIARY CARE HOSPITAL IN BHOPAL

Abhishek Chourasia*, Dr. V. K. Ramnani, Yachna Arora and Madhuri

ABSTRACT

Objective: Increasing number of reports had documented the continued emergency of resistance among Pseudomonas aeruginosa strains to common antibiotics drug, world-wide. This study investigated the antimicrobial resistance patterns of P. aeruginosa clinical isolates from hospitalized patients. Ongoing surveillance of P. aeruginosa resistant against antimicrobial is fundamental to monitor trends in susceptibility patterns and appropriately guide clinicians in choosing empirical or directed therapy. Material and Methods: This study was conducted in the Department of Microbiology at L. N Medical College Bhopal MP India. Fourty nine isolates of P. aeruginosa were isolated from different clinical specimens and fully characterized by standard bacteriological procedures. Antimicrobial susceptibility pattern of each isolates was carried out by the Kirby-Bauer disk diffusion method as per CLSI guidelines. Majority of P. aeruginosa were isolated from Pus, Sputum, Urine specimens. Results: The isolate pathogen shows resistance to Amikacin (18.45%), ciprofloxacin (31.74%) and Cefoperazone – sulbactam (36.50%). All the isolates were (100%) susceptible to Meropenem and Imipenem. The result confirmed the occurrence of drug resistance strains of P.aeruginosa. Meropenem, Imipenem, Amikacin, ciprofloxacin were found to be the most effective antimicrobial drugs. Conclusion: It therefore calls for a very judicious, rational treatment regimens prescription by the physicians to limit the further spread of antimicrobial resistance P. aeruginosa strains.

Keywords: Antimicrobial resistance, Pseudomonas aeruginosa, Clinical isolates.