ASSOCIATION OF SERUM CALCIUM LEVEL IN INFANT OF GESTATIONAL DIABETIC AND PRE GESTATIONAL DIABETIC MOTHER

Dr. Aniqa Tasnim*, Dr. M. A. Muttalib, Dr. Ayatun Nesa, Dr. Fahmida Kabir, Dr. Shawana Haque and Dr. Thahamina Shahabuddin

ABSTRACT

Background: Diabetes has long been associated with maternal and perinatal morbidity and mortality. Abnormal fetal metabolism during pregnancy which is complicated by maternal diabetes mellitus results in multiple neonatal sequelae. Objectives: To investigate the association of serum calcium level in infant of diabetic and pre diabetic mother. Method: To determine neonatal complications of gestational DM and compare them with Pregestational DM. A cross sectional study was performed in the department of Biochemistry and Molecule biology, BIRDEM, from July, 2016 – June 2017. Total 105 infants of diabetic mothers were taken to determine and compare the clinical outcome of infants. Among them 47 were born to Pregestational and 58 were born to gestational diabetes mellitus. Maternal history and birth history was taken. Blood glucose, S. calcium, magnesium, bilirubin level were estimated in all neonate by standard laboratory method. Result: Among 105 infants 62.9% were male and 37.1% were female. Most of the neonates 97.9% IPGDM were delivered by cesarean section. Reduced blood glucose, S. Ca2+ were found 25.5%, 36.2% in IPGDM and 19%, 12.1% in IGDM respectively. Occurrence of hypocalcemia were significantly higher (p=0.015 and p= 0.001 respectively) in infant of mother with PGDM. Conclusion: From this study we can conclude that newborn infants of diabetic mothers present with 15-30% decreased value of calcium in the first 24 hours after birth.

Keywords: Perinatal morbidity, mortality, serum calcium.